Sunday Evening Baseball is usually reserved for one of many higher video games on the MLB schedule, and a matchup between two bitter rivals ought to be sure that it lives as much as the hype tonight. The St. Louis Cardinals will host the Chicago Cubs for the rubber match of a three-game collection on Sunday, and the pitching matchup might be Shota Imanaga vs. Sonny Grey. The Cardinals (59-59) received Sport 1 of the collection 5-0 on Friday, after which the Cubs (67-49) responded with a 9-1 victory on Saturday in Sport 2.

Now the newest Cardinals vs. Cubs odds record Chicago because the -129 favourite, whereas St. Louis is a +108 underdog. The over/beneath for whole runs scored is 7.5, and first pitch is scheduled for 7:10 p.m. ET. Earlier than making any Cubs vs. Cardinals picks, you’ll want to see the MLB betting predictions from SportsLine’s confirmed mannequin. Guess on Cardinals vs. Cubs and each different MLB recreation at DraftKings, utilizing the newest DraftKings promo code, which gives new customers $200 in bonus bets immediately plus over $200 off NFL Sunday Ticket:

The SportsLine Projection Mannequin simulates each MLB recreation 10,000 instances. It entered Week 20 of the 2025 MLB season 28-23 on top-rated MLB money-line picks. It has excelled in making house run prop picks this season, returning almost 50 items of revenue. Anyone following at sportsbooks and on betting apps might have seen robust returns. Additionally see the mannequin’s picks for Twins vs. Royals and its prime MLB participant props for Sunday.

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Listed here are the mannequin’s finest bets for Cardinals vs. Cubs on Sunday:

  • Cubs to win (-129)
  • Sonny Grey over 2.5 earned runs allowed (+113)

Cubs to win (-129)

Imanaga is 8-4 on the season with a 3.12 ERA and has recorded 70 strikeouts over 89 1/3 innings. He is coming off a robust begin in opposition to the Reds, the place he solely surrendered one run and struck out seven over 6 1/3 innings for a no-decision. He additionally threw 5 scoreless innings and allowed just one hit for a win over the Cardinals on June 26 in his first recreation again from a hamstring damage that value him almost six weeks. In the meantime, the Chicago offense got here alive with 9 runs and 13 hits yesterday, and the mannequin has the Cubs successful in 62% of simulations on Sunday.

Sonny Gray over 2.5 earned runs allowed (+116)

Gray is a three-time MLB all-star and is coming off one of his best starts of the year, holding the high-powered Dodgers to one earned run over seven innings while striking out eight in a 3-2 win. However, he had been roughed up for 17 earned runs over his previous three starts (13 1/3 innings), and opponents are hitting .272 against him at home as opposed to .240 on the road. The over has hit in four of his last five starts, and the model predicts that he allows 3.0 earned runs on average tonight.

Want more MLB picks for Sunday?

You’ve seen the model’s MLB picks for Cubs vs. Cardinals. Now, get every MLB pick from No. 1 expert Bruce Marshall, who is up nearly 14 units on his last 168 MLB picks. 

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