The 2025 All-Star Recreation is within the books, and the Friday MLB schedule is loaded with 15 video games, 14 coming within the night, and all 30 MLB groups scheduled to be in motion. Probably the most high-profile matchups of the day is Cardinals vs. Diamondbacks at 9:40 p.m. ET in a showdown between groups trying to make playoff runs within the second half of the season. Andre Pallante (5-5, 4.49 ERA) is scheduled to be on the mound for Arizona, whereas Brandon Pfaadt (9-6, 5.16 ERA) is scheduled to start out for the Cardinals. Arizona is a -131 favourite (threat $131 to win $100) on the cash line within the newest Diamondbacks vs. Cardinals odds. The SportsLine Projection Mannequin is asking for a higher-scoring sport than the chances would recommend, with a projected mixed run whole of 10.1. Because of this, the mannequin is backing this sport to go Over 9 runs in its MLB greatest bets for Friday.
One other notable matchup on Friday is Astros vs. Mariners in Milwaukee at 10:10 p.m. ET. SportsLine’s mannequin is asking for the Mariners to win this matchup between the highest two groups within the AL West standings at -135 odds. Earlier than making some other MLB picks or constructing any MLB parlays, you will need to see the MLB predictions and betting recommendation from SportsLine’s confirmed laptop mannequin. You can even try our MLB prop picks and MLB house run picks for Friday.
The SportsLine Projection Mannequin simulates each MLB sport 10,000 occasions. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making house run prop picks this season, returning greater than 40 items of revenue. Anyone following at sportsbooks and on betting apps might have seen sturdy returns.
The mannequin has damaged down the MLB odds for Friday and simply revealed its high picks and MLB participant props. Combining the mannequin’s 4 picks into an MLB parlay would end in a payout of +853 (threat $100 to win $853). New customers may even reap the benefits of the DraftKings promo code providing $150 in bonus bets immediately with a $5 wager.
Listed below are its greatest bets for the MLB slate on Tuesday.
- Athletics (+1.5) on the run line vs. Cleveland Guardians (-189)
- Tampa Bay Rays cash line (-125) vs. Baltimore Orioles
- Cardinals-Diamondbacks Over 9 runs (-101)
- Seattle Mariners cash line (-135) vs. Houston Astros
- Mix these picks for a shot at a +853 payout (odds topic to alter)
Athletics (+1.5) on the run line vs. Cleveland Guardians (-189)
The Guardians and A’s each welcomed the All-Star break after each groups struggled by prolonged stretched in the course of the first half of the season. SportsLine’s mannequin is asking for this sport to be nearer than anticipated on Friday night time. The SportsLine Projection Mannequin is predicting a ultimate rating of 4.5-4.2 within the Guardians’ favor, with the Athletics overlaying on the run line in 68% of laptop simulations.
Tampa Bay Rays money line (-125) vs. Baltimore Orioles
The Orioles had a disappointing first half of the 2025 season, while the Rays did enough to stay in contention in the AL East and AL Wild Card races. SportsLine’s model is backing the Rays at home on Friday night. The SportsLine Projection Model is predicting a final score of 5.0-4.3 in the Rays’ favor, with Tampa Bay covering in 62% of computer simulations.
Cardinals-Diamondbacks Over 9 runs (-101)
Both starting pitchers in this matchup have struggled at times this season with the Cardinals’ Andre Pallante entering with a 4.49 ERA and 1.30 WHIP, and Arizona’s Brandon Pfaadt entering with a 5.16 ERA and 1.31 WHIP. As such, SportsLine’s model is calling for a high-scoring game on Friday night. The SportsLine Projection Model is predicting a final score of 5.2-4.9 in the Diamondbacks’ favor, with the Over hitting in 63.5% of computer simulations.
Seattle Mariners money line (-135) vs. Houston Astros
The Mariners and Astros each have their sights set on making a run to the American League Playoffs during the second half of the season. This game will be played at T-Mobile Park in Seattle, and SportsLine’s model is giving the Mariners a slight edge. The SportsLine Projection Model is predicting a final score of 4.2-3.5 in the Mariners’ favor, with Seattle covering in 63% of computer simulations.
Want more MLB picks for today?
You’ve seen some of the model’s MLB best bets for Friday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see today’s top MLB picks from expert Matt Severance, who’s on a sizzling 183-110 roll on his last 293 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up over 10 units.
